Drug General Information
Drug ID	D0T4WL
Former ID	DNC013586
Drug Name	1-hydroxy-3-phenylurea
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529488]
Structure		Download 2D MOL 3D MOL
Formula	C7H8N2O2
Canonical SMILES	C1=CC=C(C=C1)NC(=O)NO
InChI	1S/C7H8N2O2/c10-7(9-11)8-6-4-2-1-3-5-6/h1-5,11H,(H2,8,9,10)
InChIKey	AAVSQBMWOCNSDL-UHFFFAOYSA-N
PubChem Compound ID	81786
Target and Pathway
Target(s)	Tyrosine oxidase	Target Info	Inhibitor	[529488]
BioCyc Pathway	(S)-reticuline biosynthesis
	Eumelanin biosynthesis
	L-dopachrome biosynthesis
KEGG Pathway	Tyrosine metabolism
	Riboflavin metabolism
	Metabolic pathways
	Melanogenesis
PathWhiz Pathway	Riboflavin Metabolism
	Tyrosine Metabolism
WikiPathways	Dopamine metabolism
References
Ref 529488	Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. Epub 2008 May 4.Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.
Ref 529488	Bioorg Med Chem Lett. 2008 Jun 15;18(12):3607-10. Epub 2008 May 4.Analogues of N-hydroxy-N'-phenylthiourea and N-hydroxy-N'-phenylurea as inhibitors of tyrosinase and melanin formation.

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