Drug Information

Drug General Information
Drug ID
D0T2SJ
Former ID
DNC011640
Drug Name
A-313326
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527321]
Structure
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2D MOL

3D MOL
Formula
C30H22N4O
Canonical SMILES
CN1C=NC=C1C(C2=CC(=C(C=C2)C#N)C3=CC=CC4=CC=CC=C43)OCC5=<br />CC=C(C=C5)C#N
InChI
1S/C30H22N4O/c1-34-20-33-18-29(34)30(35-19-22-11-9-21(16-31)10-12-22)24-13-14-25(17-32)28(15-24)27-8-4-6-23-5-2-3-7-26(23)27/h2-15,18,20,30H,19H2,1H3
InChIKey
ZBRVJLSHNVWEKS-UHFFFAOYSA-N
PubChem Compound ID
23646371
Target and Pathway
Target(s) Protein farnesyltransferase beta subunit Target Info Inhibitor [527321]
Geranylgeranyl transferase type I beta subunit Target Info Inhibitor [527321]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
References
Ref 527321Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
Ref 527321Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8.Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.

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