Drug General Information
Drug ID
D0T2GA
Former ID
DIB020609
Drug Name
ONO-8713
Synonyms
ONO8713; ONO 8713
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539223]
Structure
Download
2D MOL
Formula
C25H24F3NO6S
InChI
InChI=1S/C25H24F3NO6S/c1-17(2)15-29(36(32,33)24-4-3-13-34-24)21-11-10-20(25(26,27)28)14-22(21)35-16-19-7-5-18(6-8-19)9-12-23(30)31/h3-14,17H,15-16H2,1-2H3,(H,30,31)/b12-9+
InChIKey
LOQMSUDLLHPPHQ-FMIVXFBMSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Prostaglandin E2 receptor EP3 subtype Target Info Agonist [534595]
Prostaglandin E2 receptor, EP1 subtype Target Info Antagonist [525601]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04020:Calcium signaling pathway
Pathways in cancer
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Reactome Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 539223(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1921).
Ref 525601New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor. Bioorg Med Chem Lett. 1999 Sep 20;9(18):2699-704.
Ref 534595Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

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