Drug General Information
Drug ID
D0T2AD
Former ID
DNC001284
Drug Name
SB 225002
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543076]
Structure
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2D MOL

3D MOL

Formula
C13H10BrN3O4
InChI
InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChIKey
MQBZVUNNWUIPMK-UHFFFAOYSA-N
CAS Number
CAS 131707-23-8
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) High affinity interleukin-8 receptor B Target Info Antagonist [535300]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR2-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543076(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 833).
Ref 535300Interleukin-8 receptor antagonists in pulmonary diseases. Curr Opin Pharmacol. 2001 Jun;1(3):242-7.

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