Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0T1RT
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| Former ID |
DIB009015
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| Drug Name |
Gamma secretase inhibitors
|
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| Synonyms |
Gamma secretase inhibitors (Alzheimer's disease); Gamma secretase inhibitors (Alzheimer's disease), Harvard Medical Institute
|
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Investigative | [552065] | ||
| Company |
Brigham & Women's Hospital
|
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1ccc2c(c1)cc(cc2)C(CCN(Cc1ccc(c(c1)F)F)C(C)C)O
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| Target and Pathway | |||||
| Target(s) | Amyloid beta A4 protein | Target Info | Inhibitor | [543619] | |
| KEGG Pathway | Notch signaling pathway | ||||
| Alzheimer's disease | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Degradation of the extracellular matrix | |||||
| Regulated proteolysis of p75NTR | |||||
| NRIF signals cell death from the nucleus | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| EPH-ephrin mediated repulsion of cells | |||||
| References | |||||
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