Drug General Information
Drug ID	D0T0YI
Former ID	DNC011243
Drug Name	4-nitrophenyl phosphate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531156]
Structure		Download 2D MOL 3D MOL
Formula	C6H6NO6P
Canonical SMILES	C1=CC(=CC=C1[N+](=O)[O-])OP(=O)(O)O
InChI	1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)
InChIKey	XZKIHKMTEMTJQX-UHFFFAOYSA-N
CAS Number	CAS 330-13-2
PubChem Compound ID	378
Target and Pathway
Target(s)	Carbonic anhydrase I	Target Info	Inhibitor	[531156]
	Carbonic anhydrase	Target Info	Inhibitor	[531156]
	Carbonic anhydrase II	Target Info	Inhibitor	[531156]
KEGG Pathway	Nitrogen metabolismhsa00910:Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretion
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor network
PathWhiz Pathway	Gastric Acid Production
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 531156	Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases.
Ref 531156	Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12. Epub 2010 Aug 26.Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of |A- but not of |A-, |?- and |?-carbonic anhydrases.

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