Drug General Information
Drug ID
D0SR4T
Former ID
DIB013630
Drug Name
PHENSERINE TARTRATE
Synonyms
N-Phenylcarbamic acid (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl ester L-tartrate; (-)-5-O-(N-Phenylcarbamoyl)eseroline L-tartrate
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Preclinical [547033]
Structure
Download
2D MOL

3D MOL

Formula
C20H23N3O2
Canonical SMILES
CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C
InChI
1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m1/s1
InChIKey
PBHFNBQPZCRWQP-QUCCMNQESA-N
CAS Number
CAS 101246-66-6
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [527603], [551871]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 547033Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012344)
Ref 527603An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res. 2005 Jul;2(3):281-90.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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