Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0SH2X
|
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| Former ID |
DIB011723
|
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| Drug Name |
Amocarzine
|
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| Synonyms |
Phenthiourezine; Thiocarbamazine; CGP-6140; S-80016
|
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| Drug Type |
Small molecular drug
|
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| Indication | Helminth infection [ICD9: 001-139; ICD10:A00-B99] | Phase 3 | [1] | ||
| Company |
Novartis AG
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H21N5O2S
|
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| Canonical SMILES |
CN1CCN(CC1)C(=S)Nc2ccc(Nc3ccc(cc3)[N+](=O)[O-])cc2
|
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| InChI |
1S/C18H21N5O2S/c1-21-10-12-22(13-11-21)18(26)20-16-4-2-14(3-5-16)19-15-6-8-17(9-7-15)23(24)25/h2-9,19H,10-13H2,1H3,(H,20,26)
|
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| InChIKey |
UFLRJROFPAGRPN-UHFFFAOYSA-N
|
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| CAS Number |
CAS 36590-19-9
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Acetylcholinesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Glycerophospholipid metabolism | ||||
| Cholinergic synapse | |||||
| PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| Pathway Interaction Database | ATF-2 transcription factor network | ||||
| PathWhiz Pathway | Phospholipid Biosynthesis | ||||
| WikiPathways | Monoamine Transport | ||||
| Biogenic Amine Synthesis | |||||
| Acetylcholine Synthesis | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| References | |||||
| REF 1 | The safety and efficacy of amocarzine in African onchocerciasis and the influence of ivermectin on the clinical and parasitological response to treatment. Ann Trop Med Parasitol. 1997 Apr;91(3):281-96. | ||||
| REF 2 | Activity, mechanism of action and pharmacokinetics of 2-tert-butylbenzothiazole and CGP 6140 (amocarzine) antifilarial drugs. Acta Trop. 1992 Aug;51(3-4):195-211. | ||||
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