Drug Information

Drug General Information
Drug ID
D0SD9V
Former ID
DNCL001690
Drug Name
Flupirtine
Drug Type
Small molecular drug
Indication Cancer pain; Fibromyalgia [ICD9: 140-229, 338, 780, 729.1; ICD10:R52, G89, M79.7] Phase 2 [522237], [539675]
Company
Adeona Pharmaceuticals; MI Meda Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C15H17FN4O2
InChI
InChI=1S/C15H17FN4O2/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20)
InChIKey
JUUFBMODXQKSTD-UHFFFAOYSA-N
CAS Number
CAS 56995-20-1
PubChem Compound ID
53276
PubChem Substance ID
7814906, 8183006, 11111201, 14800640, 34717383, 47647593, 50064925, 50111073, 57313508, 77915713, 90341043, 93299608, 96024673, 103555997, 104301761, 124749800, 124880148, 124880149, 126658653, 126686248, 128330548, 134224990, 135047758, 135650276, 137005700, 137255514, 139028353, 162187716, 164193606, 174006272, 175427080, 179150677, 196105444, 198976803, 210275567, 210281215, 223398980, 223674379, 224336873, 226413200, 241376151, 250133628, 252156847, 252657738
SuperDrug ATC ID
N02BG07
Target and Pathway
Target(s) KCNQ voltage-gated potassium channel Target Info Modulator [544094]
KEGG Pathway Adrenergic signaling in cardiomyocytes
Cholinergic synapse
Gastric acid secretion
Pancreatic secretion
Protein digestion and absorption
Vibrio cholerae infection
References
Ref 522237ClinicalTrials.gov (NCT00623415) Flupirtine as Oral Treatment in Multiple Sclerosis. U.S. National Institutes of Health.
Ref 539675(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2598).
Ref 544094Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. Br J Pharmacol. 2009 August; 157(7): 1241-1249.

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