Drug General Information
Drug ID	D0S9SX
Former ID	DNC005794
Drug Name	4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527737]
Structure		Download 2D MOL 3D MOL
Formula	C17H16N2S
Canonical SMILES	CCC1=NC(=C(S1)C2=CC=NC=C2)C3=CC(=CC=C3)C
InChI	1S/C17H16N2S/c1-3-15-19-16(14-6-4-5-12(2)11-14)17(20-15)13-7-9-18-10-8-13/h4-11H,3H2,1-2H3
InChIKey	QUKIIQWKXMTFAE-UHFFFAOYSA-N
PubChem Compound ID	11277481
Target and Pathway
Target(s)	Mitogen-activated protein kinase 14	Target Info	Inhibitor	[527737]
KEGG Pathway	MAPK signaling pathway
	Rap1 signaling pathway
	FoxO signaling pathway
	Sphingolipid signaling pathway
	Adrenergic signaling in cardiomyocytes
	VEGF signaling pathway
	Osteoclast differentiation
	Signaling pathways regulating pluripotency of stem cells
	Platelet activation
	Toll-like receptor signaling pathway
	NOD-like receptor signaling pathway
	RIG-I-like receptor signaling pathway
	T cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	TNF signaling pathway
	Leukocyte transendothelial migration
	Neurotrophin signaling pathway
	Retrograde endocannabinoid signaling
	Dopaminergic synapse
	Inflammatory mediator regulation of TRP channels
	GnRH signaling pathway
	Progesterone-mediated oocyte maturation
	Prolactin signaling pathway
	Amyotrophic lateral sclerosis (ALS)
	Epithelial cell signaling in Helicobacter pylori infection
	Shigellosis
	Salmonella infection
	Pertussis
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Tuberculosis
	Hepatitis C
	Influenza A
	Epstein-Barr virus infection
	Proteoglycans in cancer
NetPath Pathway	IL5 Signaling Pathway
	FSH Signaling Pathway
	TCR Signaling Pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Angiogenesis
	B cell activation
	EGF receptor signaling pathway
	FGF signaling pathway
	Interferon-gamma signaling pathway
	Oxidative stress response
	Parkinson disease
	TGF-beta signaling pathway
	Toll receptor signaling pathway
	VEGF signaling pathway
	Ras Pathway
	p53 pathway feedback loops 2
	p38 MAPK pathway
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	BCR signaling pathway
	p73 transcription factor network
	p38 MAPK signaling pathway
	Atypical NF-kappaB pathway
	IL4-mediated signaling events
	CD40/CD40L signaling
	IL12-mediated signaling events
	Regulation of p38-alpha and p38-beta
	CDC42 signaling events
	Angiopoietin receptor Tie2-mediated signaling
	FAS (CD95) signaling pathway
	Thromboxane A2 receptor signaling
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	Glucocorticoid receptor regulatory network
	IL2-mediated signaling events
	Rapid glucocorticoid signaling
	Regulation of Androgen receptor activity
	ATF-2 transcription factor network
	IL6-mediated signaling events
	p38 signaling mediated by MAPKAP kinases
	Retinoic acid receptors-mediated signaling
	CXCR3-mediated signaling events
	Signaling mediated by p38-alpha and p38-beta
	EPO signaling pathway
	Signaling events mediated by VEGFR1 and VEGFR2
	p53 pathway
	S1P2 pathway
	Trk receptor signaling mediated by the MAPK pathway
	VEGFR3 signaling in lymphatic endothelium
	FGF signaling pathway
	RAC1 signaling pathway
	Regulation of retinoblastoma protein
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
Reactome	NOD1/2 Signaling Pathway
	p38MAPK events
	ERK/MAPK targets
	Activation of PPARGC1A (PGC-1alpha) by phosphorylation
	Oxidative Stress Induced Senescence
	CDO in myogenesis
	DSCAM interactions
	ADP signalling through P2Y purinoceptor 1
	Platelet sensitization by LDL
	VEGFA-VEGFR2 Pathway
	activated TAK1 mediates p38 MAPK activation
	Activation of the AP-1 family of transcription factors
	KSRP (KHSRP) binds and destabilizes mRNA
WikiPathways	Toll-like receptor signaling pathway
	Monoamine Transport
	Serotonin HTR1 Group and FOS Pathway
	TCR Signaling Pathway
	Senescence and Autophagy in Cancer
	Interferon type I signaling pathways
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	MAPK Cascade
	Oxidative Stress
	p38 MAPK Signaling Pathway
	IL-4 Signaling Pathway
	MAPK Signaling Pathway
	TGF beta Signaling Pathway
	Kit receptor signaling pathway
	Cardiac Hypertrophic Response
	MAP kinase activation in TLR cascade
	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	Nanoparticle-mediated activation of receptor signaling
	Structural Pathway of Interleukin 1 (IL-1)
	JAK/STAT
	Amyotrophic lateral sclerosis (ALS)
	Alpha 6 Beta 4 signaling pathway
	Cardiac Progenitor Differentiation
	BDNF signaling pathway
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Parkinsons Disease Pathway
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	B Cell Receptor Signaling Pathway
	Prostate Cancer
	TSLP Signaling Pathway
	TWEAK Signaling Pathway
	FSH signaling pathway
	Leptin signaling pathway
	RANKL/RANK Signaling Pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	IL-1 signaling pathway
	Signal amplification
	Platelet homeostasis
	NGF signalling via TRKA from the plasma membrane
	Myogenesis
	DSCAM interactions
	MicroRNAs in cardiomyocyte hypertrophy
	Angiogenesis
	Physiological and Pathological Hypertrophy of the Heart
	Regulation of toll-like receptor signaling pathway
References
Ref 527737	J Med Chem. 2005 Sep 22;48(19):5966-79.Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.
Ref 527737	J Med Chem. 2005 Sep 22;48(19):5966-79.Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

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