Drug Information
Drug General Information | |||||
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Drug ID |
D0S9DA
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Former ID |
DCL000402
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Drug Name |
GSK1034702
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Drug Type |
Small molecular drug
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Indication | Schizophrenia; Dementia [ICD9: 290-294, 295; ICD10:F01-F07, F20] | Phase 1 | [1] | ||
Company |
GSK
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Structure |
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Download2D MOL |
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Formula |
C20H24O4
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Canonical SMILES |
CC1=CC(=CC(=C1CC2=CC(=C(C=C2)O)C(C)C)C)OCC(=O)O
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InChI |
1S/C20H24O4/c1-12(2)17-9-15(5-6-19(17)21)10-18-13(3)7-16(8-14(18)4)24-11-20(22)23/h5-9,12,21H,10-11H2,1-4H3,(H,22,23)
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InChIKey |
QNAZTOHXCZPOSA-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
14826555, 17396609, 24154997, 45284526, 79888616, 84975215, 85182421, 92098493, 92708720, 96026061, 99443896, 103023065, 103023068, 103327605, 104009556, 123055319, 127346294, 129046650, 134339039, 134340044, 135261431, 135650297, 137468709, 160647443, 160968504, 163620816, 172919515, 184824208, 198942875, 208012256, 223445157, 226626525, 241377054, 249691224, 252158166, 252481017
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Target and Pathway | |||||
Target(s) | Muscarinic acetylcholine receptor M1 | Target Info | Agonist | [2] | |
KEGG Pathway | Calcium signaling pathway | ||||
cAMP signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
PI3K-Akt signaling pathway | |||||
Cholinergic synapse | |||||
Regulation of actin cytoskeleton | |||||
PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
Reactome | Muscarinic acetylcholine receptors | ||||
G alpha (q) signalling events | |||||
WikiPathways | Monoamine GPCRs | ||||
Calcium Regulation in the Cardiac Cell | |||||
Regulation of Actin Cytoskeleton | |||||
GPCRs, Class A Rhodopsin-like | |||||
Gastrin-CREB signalling pathway via PKC and MAPK | |||||
Secretion of Hydrochloric Acid in Parietal Cells | |||||
GPCR ligand binding | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028844) | ||||
REF 2 | Clinical pipeline report, company report or official report of GlaxoSmithKline (2009). | ||||
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