Drug General Information
Drug ID	D0S8YL
Former ID	DIB011941
Drug Name	Tomelukast
Synonyms	LY-171883
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Terminated	[544534]
Company	Eli Lilly & Co
Structure		Download 2D MOL 3D MOL
Formula	C16H22N4O3
Canonical SMILES	n1nc(n[nH]1)CCCOc1c(c(c(cc1)C(=O)C)O)CCC
CAS Number	CAS 88107-10-2
PubChem Compound ID	3969
Target and Pathway
Target(s)	Cysteinyl leukotriene receptor 1	Target Info	Modulator
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	IL4 Signaling Pathway
	IL3 Signaling Pathway
Pathway Interaction Database	Endothelins
Reactome	Leukotriene receptors
	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544534	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000075)

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