Drug Information

Drug General Information
Drug ID
D0S8HD
Former ID
DIB015911
Drug Name
PEP-223/CoVaccine HT
Synonyms
Prostate cancer vaccine, Pepscan/Novartis; Prostate cancer vaccine, Pepscan/PowderJect; Prostate cancer vaccine(anti-GnRH, TDK), Pepscan
Drug Type
Vaccine
Indication Prostate cancer [ICD9: 185; ICD10:C61] Phase 1/2 [522656]
Company
Pepscan Systems BV
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info [543648]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 522656ClinicalTrials.gov (NCT00895466) Efficacy and Safety Study of the Therapeutic Vaccine PEP223 in Prostate Cancer Patients. U.S. National Institutes of Health.
Ref 543648(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256).

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