Drug General Information
Drug ID
D0S7MJ
Former ID
DNC009024
Drug Name
(S)-N-(1-phenylethyl)acetimidamide hydrobromide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531201]
Structure
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2D MOL

3D MOL

Formula
C10H15BrN2
Canonical SMILES
CC(C1=CC=CC=C1)N=C(C)N.Br
InChI
1S/C10H14N2.BrH/c1-8(12-9(2)11)10-6-4-3-5-7-10;/h3-8H,1-2H3,(H2,11,12);1H/t8-;/m0./s1
InChIKey
SXSWEEJYFGUAON-QRPNPIFTSA-N
PubChem Compound ID
Target and Pathway
Target(s) Nitric oxide synthase, inducible Target Info Inhibitor [531201]
BioCyc Pathway Citrulline-nitric oxide cycle
KEGG Pathway Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancer
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
ATF-2 transcription factor network
IL23-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
HIF-1-alpha transcription factor network
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Type II interferon signaling (IFNG)
Spinal Cord Injury
AGE/RAGE pathway
Effects of Nitric Oxide
References
Ref 531201Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. Epub 2010 Sep 17.N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.
Ref 531201Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. Epub 2010 Sep 17.N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.

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