Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S6SN
|
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| Former ID |
DIB018678
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| Drug Name |
6-hydroxymelatonin
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| Synonyms |
6-OH-MLT; 6-OH-melatonin
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C13H16N2O3
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| InChI |
InChI=1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
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| InChIKey |
OMYMRCXOJJZYKE-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7954, 893936, 6755094, 8151317, 11111254, 15246386, 17405174, 24278458, 29221059, 46500364, 47440487, 47810987, 47885611, 48185191, 48259464, 49747735, 49859680, 50106421, 50106422, 53777718, 57321050, 76900860, 85086806, 85229955, 85231069, 87692435, 90341208, 92297621, 92303802, 93576058, 103357373, 104298938, 121361350, 124749857, 124799820, 124880276, 125660570, 126524998, 128832333, 134982536, 135649850, 136350480, 137188864, 137242412, 144233494, 162090920, 163132057, 163564566, 164174528, 164842634
|
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| Target and Pathway | |||||
| Target(s) | Melatonin receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Circadian entrainment | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1347). | ||||
| REF 2 | Characterization of a retinal melatonin receptor. J Pharmacol Exp Ther. 1985 Aug;234(2):395-401. | ||||
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