Drug Information
Drug General Information | |||||
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Drug ID |
D0S6ME
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Former ID |
DNC012995
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Drug Name |
6-benzyl-3-propoxycarbonyl-4-quinolone
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C20H19NO3
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Canonical SMILES |
CCCOC(=O)C1=CNC2=C(C1=O)C=C(C=C2)CC3=CC=CC=C3
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InChI |
1S/C20H19NO3/c1-2-10-24-20(23)17-13-21-18-9-8-15(12-16(18)19(17)22)11-14-6-4-3-5-7-14/h3-9,12-13H,2,10-11H2,1H3,(H,21,22)
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InChIKey |
JIOMLDXNFGNQFW-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [1] | |
Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [1] | ||
Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [1] | ||
Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [1] | ||
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Retrograde endocannabinoid signaling | |||||
GABAergic synapse | |||||
Morphine addiction | |||||
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
Serotonergic synapse | |||||
Nicotine addiction | |||||
Reactome | Ligand-gated ion channel transport | ||||
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport | |||||
GABA A receptor activation | |||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Iron uptake and transport | |||||
References | |||||
REF 1 | J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling. | ||||
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