Drug Information

Drug General Information
Drug ID
D0S4VR
Former ID
DNC004334
Drug Name
(1H-Benzoimidazol-5-yl)-(1H-imidazol-2-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534315]
Structure
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2D MOL

3D MOL
Formula
C10H9N5
Canonical SMILES
C1=CC2=C(C=C1NC3=NC=CN3)NC=N2
InChI
1S/C10H9N5/c1-2-8-9(14-6-13-8)5-7(1)15-10-11-3-4-12-10/h1-6H,(H,13,14)(H2,11,12,15)
InChIKey
NFSIDEIKDWWMOX-UHFFFAOYSA-N
PubChem Compound ID
10655607
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Inhibitor [534315]
Alpha-2A adrenergic receptor Target Info Inhibitor [534315]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 534315J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Ref 534315J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.

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