Drug General Information
Drug ID	D0S4JY
Former ID	DIB013453
Drug Name	Ro-24-4736
Drug Type	Small molecular drug
Indication	Septic shock [ICD9: 785.52; ICD10:A41.9]		Discontinued in Phase 2	[544808]
Company	Roche Holding AG
Structure		Download 2D MOL 3D MOL
Formula	C31H20ClN5OS
Canonical SMILES	c12c(C(=NCc3n1c(nn3)C)c1c(Cl)cccc1)cc(s2)C#CCn1c(=O)c2c<br />(c3c1cccc3)cccc2
CAS Number	CAS 125030-71-9
PubChem Compound ID	60775
Target and Pathway
Target(s)	Platelet-activating factor receptor	Target Info	Antagonist	[528091]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
NetPath Pathway	IL5 Signaling Pathway
	Leptin Signaling Pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 544808	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001180)
Ref 528091	Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736. J Pharmacol Exp Ther. 1991 Oct;259(1):78-85.

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