Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0S4JY
|
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| Former ID |
DIB013453
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| Drug Name |
Ro-24-4736
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| Drug Type |
Small molecular drug
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| Indication | Septic shock [ICD9: 785.52; ICD10:A41.9] | Discontinued in Phase 2 | [1] | ||
| Company |
Roche Holding AG
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C31H20ClN5OS
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| Canonical SMILES |
c12c(C(=NCc3n1c(nn3)C)c1c(Cl)cccc1)cc(s2)C#CCn1c(=O)c2c<br />(c3c1cccc3)cccc2
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| CAS Number |
CAS 125030-71-9
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Platelet-activating factor receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Staphylococcus aureus infection | |||||
| NetPath Pathway | IL5 Signaling Pathway | ||||
| Leptin Signaling Pathway | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (q) signalling events | |||||
| Interferon gamma signaling | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Small Ligand GPCRs | |||||
| Interferon gamma signaling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001180) | ||||
| REF 2 | Pharmacology of a potent platelet-activating factor antagonist: Ro 24-4736. J Pharmacol Exp Ther. 1991 Oct;259(1):78-85. | ||||
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