| Drug General Information |
| Drug ID |
D0S1XN
|
| Former ID |
DNC003539
|
| Drug Name |
4-(4-Benzyl-piperazin-1-yl)-7-bromo-1H-indole
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C19H20BrN3
|
| Canonical SMILES |
C1CN(CCN1CC2=CC=CC=C2)C3=C4C=CNC4=C(C=C3)Br
|
| InChI |
1S/C19H20BrN3/c20-17-6-7-18(16-8-9-21-19(16)17)23-12-10-22(11-13-23)14-15-4-2-1-3-5-15/h1-9,21H,10-14H2
|
| InChIKey |
RBUDKKJLRVBPDA-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| D(4) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
| D(3) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Gap junction
|
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Dopaminergic synapse
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04080:Neuroactive ligand-receptor interaction
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Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Nicotine pharmacodynamics pathway
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
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G alpha (i) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
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Nicotine Activity on Dopaminergic Neurons
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GPCRs, OtherWP58:Monoamine GPCRs
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|
GPCRs, Other
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| References |
| REF 1 | Bioorg Med Chem Lett. 1998 Oct 6;8(19):2675-80.New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template. |
|---|
