Drug General Information
Drug ID
D0S0XS
Former ID
DIB009192
Drug Name
SR-271425
Synonyms
BCN-326862; SW-71425; WIN-71425; 1-[2-(Diethylamino)ethylamino]-4-(formamidomethyl)-7-methoxy-9H-thioxanthen-9-one
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 1 [546998]
Structure
Download
2D MOL

3D MOL

Formula
C22H27N3O3S
Canonical SMILES
CCN(CC)CCNC1=C2C(=C(C=C1)CNC=O)SC3=C(C2=O)C=C(C=C3)OC
InChI
1S/C22H27N3O3S/c1-4-25(5-2)11-10-24-18-8-6-15(13-23-14-26)22-20(18)21(27)17-12-16(28-3)7-9-19(17)29-22/h6-9,12,14,24H,4-5,10-11,13H2,1-3H3,(H,23,26)
InChIKey
GWLFIMOOGVXSMZ-UHFFFAOYSA-N
CAS Number
CAS 155990-20-8
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Human DNA Target Info Binder [529950]
References
Ref 546998Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011907)
Ref 529950A phase I dose-escalation study of SR271425, an intravenously dosed thioxanthone analog, administered weekly in patients with refractory solid tumors. Am J Clin Oncol. 2009 Feb;32(1):9-14.

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