| Drug General Information |
| Drug ID |
D0S0RK
|
| Former ID |
DIB019857
|
| Drug Name |
flavone
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H10O2
|
| InChI |
InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H
|
| InChIKey |
VHBFFQKBGNRLFZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
12229, 81975, 589074, 621065, 894248, 3133268, 5422192, 8138030, 8157719, 10322913, 10525272, 11145517, 11352088, 11393367, 14797981, 17137132, 17389570, 17396599, 24870087, 24894806, 26697253, 26752852, 29204142, 29229149, 30279698, 32626201, 46493766, 47515677, 47960105, 48185348, 48415240, 48421829, 48425145, 49737809, 49747452, 49889785, 50113345, 51075505, 53790304, 56462798, 57326386, 57393442, 57654180, 57807511, 79531197, 85086078, 85209887, 85293760, 85843922, 87569829
|
| Target and Pathway |
| Target(s) |
Adenosine A3 receptor |
Target Info |
Antagonist |
[2]
|
|---|
| Adenosine A2b receptor |
Target Info |
Antagonist |
[2]
|
| Adenosine A1 receptor |
Target Info |
Antagonist |
[2]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Vascular smooth muscle contraction
|
|
Alcoholismhsa04022:cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Sphingolipid signaling pathway
|
|
Morphine addiction
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling Pathway
|
|
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
RANKL Signaling Pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Pathway Interaction Database
|
C-MYB transcription factor network
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Reactome
|
Adenosine P1 receptors
|
|
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (s) signalling events
|
|
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Nucleotide GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
GPCRs, OtherWP80:Nucleotide GPCRs
|
|
GPCR ligand binding
|
|
GPCR downstream signalingWP80:Nucleotide GPCRs
|
|
GPCR downstream signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 409). |
|---|
| REF 2 | J Med Chem. 1996 Jun 7;39(12):2293-301.Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. |
|---|
