Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0RN5A
|
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| Former ID |
DIB018350
|
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| Drug Name |
[3H]naloxone
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| Synonyms |
[N-allyl-2,3-3H]naloxone
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H21NO4
|
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| InChI |
InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
|
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| InChIKey |
UZHSEJADLWPNLE-GRGSLBFTSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
9461, 113816, 841983, 7980073, 11039368, 11466139, 11467259, 11485797, 14777335, 14924176, 16463984, 25663897, 39317902, 46508816, 47588898, 47588899, 47662178, 47736369, 47959634, 48334383, 48416308, 49698350, 49993151, 50070720, 50104484, 53788675, 56312594, 56312596, 56352924, 57288792, 57359133, 74711224, 85787517, 92309116, 93166268, 96024937, 103170037, 103915330, 124886932, 126688739, 129442197, 134337424, 134974167, 135650684, 135651185, 137001357, 139076562, 144205559, 160964517, 162183031
|
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| Target and Pathway | |||||
| Target(s) | Mu-type opioid receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Estrogen signaling pathway | |||||
| Morphine addiction | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Enkephalin release | |||||
| Pathway Interaction Database | IL4-mediated signaling events | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | TCR Signaling Pathway | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Peptide GPCRs | |||||
| Opioid Signalling | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1676). | ||||
| REF 2 | Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4. | ||||
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