Drug Information

Drug General Information
Drug ID
D0R9VR
Former ID
DAP000559
Drug Name
Galantamine
Synonyms
GNT; Galantamin; Galantamina; Galantaminum; Galanthamine; Galanthaminum; Jilkon; Lycoremin; Lycoremine; Reminyl; Razadyne ER; Galantamina [INN-Spanish]; Galantamine [USAN:INN]; Galantaminum [INN-Latin]; Nivalin (TN); Razadyne (TN); Razadyne ER (TN); Reminyl (TN); Galantamine (USAN/INN); (-)-Galanthamine; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro(3a,3,2-ef)(2)benzazepin-6-ol
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Approved [536285], [541798]
Therapeutic Class
Parasympathomimetics
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C17H21NO3
InChI
InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
InChIKey
ASUTZQLVASHGKV-JDFRZJQESA-N
CAS Number
CAS 357-70-0
PubChem Compound ID
9651
PubChem Substance ID
10719, 584656, 584664, 606095, 831251, 7887946, 7979350, 8004402, 8156932, 11335765, 11361004, 11364165, 11366727, 11369289, 11372735, 11374555, 11377451, 11461976, 11466616, 11467736, 11486391, 11491553, 11492654, 11495085, 11537759, 14751181, 14775584, 24875119, 25646023, 26697250, 26751839, 29228225, 46391750, 46393027, 46505659, 46511027, 47206224, 47216757, 47216758, 47291111, 47515304, 47588978, 47885390, 47959724, 48259212, 48334469, 48334470, 49698570, 49972082, 53786839
ChEBI ID
ChEBI:42944
SuperDrug ATC ID
N06DA04
SuperDrug CAS ID
cas=000357700
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [537334], [537340], [537434]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 536285Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54.
Ref 541798(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6693).
Ref 537334Effects of cholinesterase inhibition on brain white matter volume in Alzheimer's disease. Neuroreport. 2009 Feb 18;20(3):285-8.
Ref 537340Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behav Brain Res. 2009 Oct 12;203(1):1-14. Epub 2009 Mar 28.
Ref 537434From symptomatic to disease modifying therapy? Recent developments in the pharmacotherapy of Alzheimer's disease. Fortschr Neurol Psychiatr. 2009 Jun;77(6):326-33. Epub 2009 Jun 5.

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