Drug Information

Drug General Information
Drug ID
D0R8PL
Former ID
DNC009359
Drug Name
11-Hexanoyloxy-N-n-propylnoraporphine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529686]
Structure
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2D MOL

3D MOL
Formula
C25H31NO2
Canonical SMILES
CCCCCC(=O)OC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)CCC
InChI
1S/C25H31NO2/c1-3-5-6-13-23(27)28-22-12-8-10-19-17-21-24-18(14-16-26(21)15-4-2)9-7-11-20(24)25(19)22/h7-12,21H,3-6,13-17H2,1-2H3/t21-/m1/s1
InChIKey
IHDFATFMTYOPPY-OAQYLSRUSA-N
PubChem Compound ID
44579030
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [529686]
Dopamine D1 receptor Target Info Inhibitor [529686]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
cAMP signaling pathway
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 529686Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. Epub 2008 Aug 28.N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.
Ref 529686Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. Epub 2008 Aug 28.N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.

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