Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R6MT
|
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| Former ID |
DIB020081
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| Drug Name |
isobutylmethylxanthine
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| Synonyms |
methylisobutylxanthine
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C10H14N4O2
|
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| InChI |
InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
|
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| InChIKey |
APIXJSLKIYYUKG-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
440021, 586297, 603446, 831838, 3139713, 4667750, 4667751, 6436339, 7888298, 7980296, 8150163, 8152377, 10517163, 11111325, 11120336, 11120824, 11121312, 11121752, 11122232, 11336097, 11361336, 11362907, 11364974, 11365469, 11367536, 11368031, 11370098, 11371005, 11371006, 11372975, 11373137, 11373632, 11374483, 11375698, 11376193, 11378269, 11404372, 11462308, 11485426, 11485546, 11489521, 11489551, 11491773, 11492866, 12157646, 14822728, 15195998, 17405203, 24277680, 24896107
|
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| Target and Pathway | |||||
| Target(s) | Adenosine A1 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| cAMP signaling pathway | |||||
| Sphingolipid signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Morphine addiction | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| RANKL Signaling Pathway | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Reactome | Adenosine P1 receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Nucleotide GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 388). | ||||
| REF 2 | Species difference in the G protein selectivity of the human and bovine A1-adenosine receptor. J Biol Chem. 1994 Dec 23;269(51):32077-84. | ||||
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