Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R6FJ
|
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| Former ID |
DNC011502
|
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| Drug Name |
NORHARMANE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C11H8N2
|
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| InChI |
InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
|
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| InChIKey |
AIFRHYZBTHREPW-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
122166, 646046, 855536, 3134108, 5536206, 7980024, 8189408, 10321411, 10515297, 11364026, 11366588, 11369150, 11371642, 11375670, 11377312, 11448734, 11484172, 11488404, 11490557, 11493729, 11494946, 11537690, 12015776, 14843142, 22388129, 24897776, 26679360, 26746906, 29204446, 30134734, 32469833, 37423398, 43121816, 47217266, 47811249, 48259727, 48414245, 49748324, 49748325, 49857602, 50100962, 50103899, 50734380, 53787843, 56422412, 57315208, 81093147, 85088300, 85315305, 85789440
|
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| Target and Pathway | |||||
| Target(s) | Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [2] | |
| Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Retrograde endocannabinoid signaling | |||||
| GABAergic synapse | |||||
| Morphine addiction | |||||
| Nicotine addiction | |||||
| Reactome | Ligand-gated ion channel transport | ||||
| GABA A receptor activation | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Iron uptake and transport | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8222). | ||||
| REF 2 | J Med Chem. 1988 Sep;31(9):1854-61.Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore. | ||||
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