Drug Information

Drug General Information
Drug ID
D0R5RR
Former ID
DAP000849
Drug Name
Clofarabine
Synonyms
CAFdA; CFB; Clofarabina; Clofarabinum; Clofarex; Clolar; Evoltra; Clofarabine [USAN]; Clolar (TN); Evoltra (TN); Clofarabine (USAN/INN); Clolar, Evoltra, Clofarabine; Cl-F-Ara-A; (2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine; 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine; 2-Cl-2'-F-araA; 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine; 3S211048
Drug Type
Small molecular drug
Indication Myelodysplastic syndrome; Acute lymphoblastic leukemia [ICD9: 238.7, 204.0, 556; ICD10:D46, C91.0] Approved [527466], [536361], [541885], [551871]
Therapeutic Class
Anticancer Agents
Structure
Download
2D MOL

3D MOL
Formula
C10H11ClFN5O3
InChI
InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
InChIKey
WDDPHFBMKLOVOX-AYQXTPAHSA-N
CAS Number
CAS 123318-82-1
PubChem Compound ID
119182
PubChem Substance ID
8149071, 10238376, 10317422, 12014412, 14800615, 14800616, 29300120, 46504968, 47205855, 50027432, 56459308, 57339361, 71821361, 77716344, 81092867, 92309003, 92719465, 93608050, 99437031, 99444025, 103707445, 104407717, 109610765, 118048878, 124757091, 125163895, 126584329, 126620778, 126652234, 126671067, 129564367, 134223319, 134338128, 135073562, 135698306, 136920392, 136946661, 136949087, 137005624, 141857409, 143493352, 144115841, 144205735, 152058774, 152237732, 152258941, 160647786, 160963976, 162011506, 162176704
SuperDrug ATC ID
L01BB06
Target and Pathway
Target(s) Ribonucleoside-diphosphate reductase Target Info Inhibitor [536496]
DNA Target Info Binder [536496]
References
Ref 5274662004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541885(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6802).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536496Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30.

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