Drug General Information
Drug ID
D0R4YQ
Former ID
DIB016693
Drug Name
CB-813
Synonyms
CB-813d; Recombinant human factor VIIa (Alterase, hemophilia), Catalyst Biosciences; RhFVIIa (Alterase, hemophilia), Catalyst Biosciences; Recombinant human factor VIIa (Alterase, hemophilia), Catalyst Biosciences/Wyeth Pharmaceuticals
Drug Type
Small molecular drug
Indication Hemophilia [ICD9: 286; ICD10:D66-D68] Phase 1 [548685]
Company
Catalyst biosciences; pfizer
Structure
Download
2D MOL

3D MOL

Formula
C20H28ClNO2
Canonical SMILES
C1CCC(CC1)C2=C(C=C(C=C2)CCCC(=O)N3CCOCC3)Cl
InChI
1S/C20H28ClNO2/c21-19-15-16(9-10-18(19)17-6-2-1-3-7-17)5-4-8-20(23)22-11-13-24-14-12-22/h9-10,15,17H,1-8,11-14H2
InChIKey
GCECPNQPPJYYOR-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Coagulation factor VII Target Info Modulator [550533]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Angiogenesis
Blood coagulation
PathWhiz Pathway Coagulation
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
Extrinsic Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
WikiPathways Complement and Coagulation Cascades
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
Circadian Clock
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 548685Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027663)
Ref 550533Clinical pipeline report, company report or official report of Catalyst Biosciences.

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