Drug Information
Drug General Information | |||||
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Drug ID |
D0R3EL
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Former ID |
DCL000372
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Drug Name |
GSK184072
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Drug Type |
Small molecular drug
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Indication | Colon cancer; Hematologic cancers; Type 2 diabetes [ICD9: 140-229, 250, 250.00, 250.02; ICD10:E08-E13, E11] | Discontinued in Phase 2 | [548320] | ||
Company |
GSK
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Structure |
Download2D MOL |
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Formula |
C12H18N2O3
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Canonical SMILES |
CC(C)CC1=NC(=CC(C)C)C(=O)N(C1=O)O
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InChI |
1S/C12H18N2O3/c1-7(2)5-9-11(15)14(17)12(16)10(13-9)6-8(3)4/h5,7-8,17H,6H2,1-4H3/b9-5-
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InChIKey |
SIXHCCPAJIVTOY-UITAMQMPSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | NAD-dependent deacetylase sirtuin-1 | Target Info | Activator | [550963] | |
PANTHER Pathway | p53 pathway | ||||
Pathway Interaction Database | p73 transcription factor network | ||||
Signaling events mediated by HDAC Class III | |||||
E2F transcription factor network | |||||
HIF-2-alpha transcription factor network | |||||
Signaling events mediated by HDAC Class I | |||||
FoxO family signaling | |||||
Regulation of Androgen receptor activity | |||||
Regulation of retinoblastoma protein | |||||
References |
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