| Drug General Information |
| Drug ID |
D0R2WK
|
| Former ID |
DNC013651
|
| Drug Name |
NVP-TAE684
|
| Drug Type |
Small molecular drug
|
| Indication |
Lymphoma [ICD9: 202.8, 208.9; ICD10:C81-C86]
|
Investigative |
[1]
|
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| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C30H40ClN7O3S
|
| InChI |
InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
|
| InChIKey |
QQWUGDVOUVUTOY-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
24420733, 26586860, 41797425, 99205953, 99436912, 103583785, 103904598, 104099207, 109692872, 124757006, 124947877, 125163811, 125434026, 126582049, 126738823, 131480685, 134350856, 134964417, 135642892, 135686038, 135686039, 135686060, 135686061, 135697739, 135727576, 136340215, 136367306, 136367856, 138475841, 143499019, 144116303, 152239917, 152258113, 152344265, 160646952, 162011368, 162037441, 162202654, 172650400, 174006515, 174530590, 177748736, 178102340, 180190843, 185998799, 187071979, 188899497, 198959115, 223680889, 223705047
|
| Target and Pathway |
| Target(s) |
Insulin receptor |
Target Info |
Inhibitor |
[2]
|
|---|
|
KEGG Pathway
|
Ras signaling pathway
|
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Rap1 signaling pathway
|
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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FoxO signaling pathway
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PI3K-Akt signaling pathway
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AMPK signaling pathway
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Adherens junction
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Insulin signaling pathway
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Ovarian steroidogenesis
|
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Type II diabetes mellitus
|
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Non-alcoholic fatty liver disease (NAFLD)
|
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Aldosterone-regulated sodium reabsorption
|
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NetPath Pathway
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TGF_beta_Receptor Signaling Pathway
|
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PANTHER Pathway
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
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Insulin/IGF pathway-protein kinase B signaling cascade
|
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PI3 kinase pathway
|
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Pathway Interaction Database
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Insulin Pathway
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Signaling events mediated by PTP1B
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Signaling events mediated by TCPTP
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Insulin-mediated glucose transport
|
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PathWhiz Pathway
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Insulin Signalling
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Leucine Stimulation on Insulin Signaling
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Reactome
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IRS activation
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Signal attenuation
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Insulin receptor signalling cascade
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Insulin receptor recycling
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WikiPathways
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DNA Damage Response (only ATM dependent)
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Insulin Signaling
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Nanoparticle triggered autophagic cell death
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AGE/RAGE pathway
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Signaling by Insulin receptor
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Folate Metabolism
|
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Type II diabetes mellitus
|
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Vitamin B12 Metabolism
|
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Selenium Micronutrient Network
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|
AMPK Signaling
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5714). |
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| REF 2 | Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5. Epub 2006 Dec 21.Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. |
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