Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0R1VL
|
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| Former ID |
DIB008949
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| Drug Name |
BIBN-99
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| Drug Type |
Small molecular drug
|
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Terminated | [1] | ||
| Company |
Boehringer Ingelheim Corp
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C31H42ClN5O3
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| Canonical SMILES |
n1(c2c(c(=O)[nH]c3c1nccc3)cc(cc2)Cl)C(=O)CN1CCC(CC1)CCC<br />N(C(=O)C(CCC)(C)C)CC
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| CAS Number |
CAS 145301-48-0
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Muscarinic acetylcholine receptor M2 | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| PI3K-Akt signaling pathway | |||||
| Cholinergic synapse | |||||
| Regulation of actin cytoskeleton | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| Reactome | Muscarinic acetylcholine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | |||||
| Calcium Regulation in the Cardiac Cell | |||||
| Regulation of Actin Cytoskeleton | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002066) | ||||
| REF 2 | Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30. | ||||
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