Drug Information

Drug General Information
Drug ID
D0R0EV
Former ID
DNC000587
Drug Name
E-6123
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [544861]
Structure
Download
2D MOL

3D MOL
Formula
C23H22ClN5OS
Canonical SMILES
CC1C2=NN=C(N2C3=C(C4=C(S3)CN(CC4)C(=O)C5CC5)C(=N1)C6=CC<br />=CC=C6Cl)C
InChI
1S/C23H22ClN5OS/c1-12-21-27-26-13(2)29(21)23-19(20(25-12)15-5-3-4-6-17(15)24)16-9-10-28(11-18(16)31-23)22(30)14-7-8-14/h3-6,12,14H,7-11H2,1-2H3/t12-/m0/s1
InChIKey
JEQVYSUCZLYBRQ-LBPRGKRZSA-N
CAS Number
CAS 131614-02-3
PubChem Compound ID
3035214
PubChem Substance ID
10048298, 12014509, 14833374, 36078747, 50035309, 50985685, 57353053, 103340947, 111638427, 134339981, 135074873
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544861Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001351)

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