| Drug General Information |
| Drug ID |
D0QN5I
|
| Former ID |
DNC008470
|
| Drug Name |
4-(furan-2-yl)thieno[3,2-d]pyrimidin-2-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H7N3OS
|
| Canonical SMILES |
C1=COC(=C1)C2=NC(=NC3=C2SC=C3)N
|
| InChI |
1S/C10H7N3OS/c11-10-12-6-3-5-15-9(6)8(13-10)7-2-1-4-14-7/h1-5H,(H2,11,12,13)
|
| InChIKey |
ARPSUXKIHNZLQL-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Adenosine A2a receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Adenosine A1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
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Vascular smooth muscle contraction
|
|
Parkinson's disease
|
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Alcoholismhsa04022:cGMP-PKG signaling pathway
|
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Sphingolipid signaling pathway
|
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Morphine addiction
|
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NetPath Pathway
|
TCR Signaling Pathway
|
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RANKL Signaling Pathway
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
|
Pathway Interaction Database
|
HIF-2-alpha transcription factor network
|
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PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Reactome
|
NGF-independant TRKA activation
|
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Adenosine P1 receptors
|
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G alpha (s) signalling events
|
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Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
Nucleotide GPCRs
|
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Monoamine Transport
|
|
GPCRs, Class A Rhodopsin-like
|
|
NGF signalling via TRKA from the plasma membrane
|
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GPCR ligand binding
|
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GPCR downstream signaling
|
|
GPCRs, OtherWP80:Nucleotide GPCRs
|
| References |
| REF 1 | Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. Epub 2008 Mar 30.Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidinesand 6-arylpurines. |
|---|
