Drug General Information
Drug ID
D0Q9TL
Former ID
DNC004521
Drug Name
L-702-539
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534459]
Structure
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2D MOL

3D MOL

Formula
C28H23NO5
Canonical SMILES
C1C2COC(O2)CC1(C3=CC(=CC=C3)COC4=CC5=C(C=C4)C(=CC(=C5)C<br />#N)C6=COC=C6)O
InChI
1S/C28H23NO5/c29-14-19-8-21-11-23(4-5-25(21)26(10-19)20-6-7-31-16-20)32-15-18-2-1-3-22(9-18)28(30)12-24-17-33-27(13-28)34-24/h1-11,16,24,27,30H,12-13,15,17H2
InChIKey
CHLJRXIFRPILDX-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) mRNA of human 5-lipoxygenase Target Info Inhibitor [534459]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 534459J Med Chem. 1997 Aug 29;40(18):2866-75.Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.
Ref 534459J Med Chem. 1997 Aug 29;40(18):2866-75.Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.

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