Drug Information

Drug General Information
Drug ID
D0Q8TD
Former ID
DNC005013
Drug Name
1-(2-Bromo-phenyl)-3-(2,4-dihydroxy-phenyl)-urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527139]
Structure
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2D MOL

3D MOL
Formula
C13H11BrN2O3
Canonical SMILES
C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)O)O)Br
InChI
1S/C13H11BrN2O3/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17)7-12(11)18/h1-7,17-18H,(H2,15,16,19)
InChIKey
UUVQJGFAYHMNII-UHFFFAOYSA-N
PubChem Compound ID
44393620
Target and Pathway
Target(s) High affinity interleukin-8 receptor A Target Info Inhibitor [527139]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Interleukin signaling pathway
Pathway Interaction Database IL8- and CXCR1-mediated signaling events
Reactome Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Differentiation Pathway
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527139Bioorg Med Chem Lett. 2004 Aug 16;14(16):4307-11.Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8(IL-8) receptor antagonists.
Ref 527139Bioorg Med Chem Lett. 2004 Aug 16;14(16):4307-11.Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8(IL-8) receptor antagonists.

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