Drug Information

Drug General Information
Drug ID
D0Q8RX
Former ID
DIB014075
Drug Name
L-368899
Drug Type
Small molecular drug
Indication Miscarriage [ICD10:O03] Discontinued in Phase 1 [539423], [546833]
Company
Merck & Co Inc
Structure
Download
2D MOL

3D MOL
Formula
C26H42N4O5S2
InChI
InChI=1S/C26H42N4O5S2/c1-19-7-5-6-8-22(19)29-12-14-30(15-13-29)37(34,35)18-26-11-9-20(25(26,2)3)17-23(26)28-24(31)21(27)10-16-36(4,32)33/h5-8,20-21,23H,9-18,27H2,1-4H3,(H,28,31)/t20-,21+,23+,26-/m1/s1
InChIKey
MWIASLNTAGRGGA-ZJPWWDJASA-N
CAS Number
CAS 148927-60-0
PubChem Compound ID
9872389
PubChem Substance ID
14837371, 15457498, 45294646, 75187848, 123096165, 123105834, 135650472, 162222305
Target and Pathway
Target(s) Oxytocin receptor Target Info Antagonist [534480]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539423(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2249).
Ref 546833Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010521)
Ref 534480Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs. Drug Metab Dispos. 1997 Oct;25(10):1113-8.

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