TTD | Drug: D0Q7AW

Drug General Information
Drug ID	D0Q7AW
Former ID	DNC011889
Drug Name	IMIRESTAT
Drug Type	Small molecular drug
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Discontinued in Phase 3	[544515]
Structure		Download 2D MOL 3D MOL
Formula	C15H8F2N2O2
Canonical SMILES	C1=CC2=C(C=C1F)C3(C4=C2C=CC(=C4)F)C(=O)NC(=O)N3
InChI	1S/C15H8F2N2O2/c16-7-1-3-9-10-4-2-8(17)6-12(10)15(11(9)5-7)13(20)18-14(21)19-15/h1-6H,(H2,18,19,20,21)
InChIKey	QCCHBHSAIQIQGO-UHFFFAOYSA-N
PubChem Compound ID	65673
Target and Pathway
Target(s)	Aldose reductase	Target Info	Inhibitor	[530231]
BioCyc Pathway	Methylglyoxal degradation III
BioCyc Pathway	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 544515	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000020)
Ref 530231	J Med Chem. 1991 Nov;34(11):3229-34.Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors.

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Drug Information