Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q5MQ
|
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| Former ID |
DNCL003107
|
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| Drug Name |
Tasimelteon
|
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| Drug Type |
Small molecular drug
|
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| Indication | Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] | Approved | [1], [2] | ||
| Company |
Vanda Pharmaceuticals
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C15H19NO2
|
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| InChI |
InChI=1S/C15H19NO2/c1-2-15(17)16-9-10-8-13(10)11-4-3-5-14-12(11)6-7-18-14/h3-5,10,13H,2,6-9H2,1H3,(H,16,17)/t10-,13+/m0/s1
|
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| InChIKey |
PTOIAAWZLUQTIO-GXFFZTMASA-N
|
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| CAS Number |
CAS 609799-22-6
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
15221060, 22609327, 40334994, 46387835, 78704256, 92722464, 96026068, 126627315, 126662442, 128966262, 135253193, 137132834, 137788131, 141198068, 160676375, 164777429, 165238001, 178103965, 180371725, 198968673, 198994004, 223444257, 223675953, 225045086, 229516194, 241124240, 251971356, 252552922, 252671867
|
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| Target and Pathway | |||||
| Target(s) | Melatonin receptor type 1B | Target Info | Agonist | [1] | |
| Melatonin receptor | Target Info | Agonist | [1] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Circadian entrainmenthsa04080:Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
| G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors) | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Small Ligand GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7393). | ||||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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