Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q5KL
|
||||
| Former ID |
DAP000964
|
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| Drug Name |
Coagulation Factor IX
|
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| Indication | Haemophilia B; Christmas disease [ICD9: 286.1; ICD10:D67] | Approved | [1], [2] | ||
| Therapeutic Class |
Anticoagulants
|
||||
| Formula |
C2041H3136N558O641S25
|
||||
| CAS Number |
CAS 9001-28-9
|
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| SuperDrug ATC ID |
B02BD04
|
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| Target and Pathway | |||||
| Target(s) | Coagulation factor Xa | Target Info | Activator | [3] | |
| KEGG Pathway | Complement and coagulation cascades | ||||
| PANTHER Pathway | Blood coagulation | ||||
| Pathway Interaction Database | Beta2 integrin cell surface interactions | ||||
| PathWhiz Pathway | Coagulation | ||||
| Reactome | Extrinsic Pathway of Fibrin Clot Formation | ||||
| Intrinsic Pathway of Fibrin Clot Formation | |||||
| Common Pathway of Fibrin Clot Formation | |||||
| Gamma-carboxylation of protein precursors | |||||
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | |||||
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | |||||
| WikiPathways | Complement and Coagulation Cascades | ||||
| Human Complement System | |||||
| PTM: gamma carboxylation, hypusine formation and arylsulfatase activation | |||||
| Blood Clotting Cascade | |||||
| Formation of Fibrin Clot (Clotting Cascade) | |||||
| References | |||||
| REF 1 | 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. | ||||
| REF 2 | Drug information of Coagulation Factor IX, 2008. eduDrugs. | ||||
| REF 3 | Haemophilia B: Christmas disease. Expert Opin Pharmacother. 2005 Aug;6(9):1517-24. | ||||
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