Drug Information

Drug General Information
Drug ID
D0Q3EW
Former ID
DIB018915
Drug Name
2np8
Synonyms
2np8
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541217]
Structure
Download
2D MOL
Formula
C21H18F3N5O
InChI
InChI=1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)
InChIKey
RDTDWGQDFJPTPD-UHFFFAOYSA-N
PubChem Compound ID
9549303
PubChem Substance ID
14720370, 16692193, 23984872, 24724434, 26758271, 44692632, 50112994, 53800967, 53812786, 80510081, 85176967, 99302628, 99302839, 99444016, 103502358, 104080726, 137220362, 137712964, 160968619, 163124719, 163688560, 175607392, 175607458, 178102554, 180372387, 204380080, 208265174, 212343928, 226971935, 241157275, 245175257
Target and Pathway
Target(s) Aurora protein kinase Target Info Inhibitor [528573]
KEGG Pathway Oocyte meiosis
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 541217(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5931).
Ref 528573Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91. Epub 2006 Nov 2.

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