Drug Information

Drug General Information
Drug ID
D0Q2EH
Former ID
DIB004656
Drug Name
Brutieridin
Synonyms
Brutieridin; Melitidin; Bergamot juice flavonoids (hypercholesterolemia), Biopharm technologies; Brutieridin/melitidin (hypercholesterolemia), Biopharm technologies
Indication Hypercholesterolemia [ICD10:E78] Investigative [543905]
Company
Biopharm Technology Corp
Structure
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2D MOL

3D MOL
Canonical SMILES
[C@@H]1([C@@H](O[C@@H]([C@H]([C@@H]1O)O)COC(=O)CC(CC(=O<br />)O)(O)C)Oc1cc2c(C(=O)C[C@H](O2)c2cc(c(cc2)OC)O)c(c1)O)O<br />[C@@H]1[C@H]([C@H]([C@@H]([C@H](O1)C)O)O)O
Target and Pathway
Target(s) 3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [543905]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretion
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol Biosynthesis
References
Ref 543905(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 639).
Ref 543905(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 639).

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