Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q0HR
|
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| Former ID |
DCL001041
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| Drug Name |
Y-931
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| Drug Type |
Small molecular drug
|
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| Indication | Schizophrenia [ICD9: 295; ICD10:F20] | Terminated | [1] | ||
| Company |
Mitsubishi Pharma
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C24H23FN4O4S
|
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| Canonical SMILES |
C[NH+]1CC[N+](=C2C3=C(NC4=C(N2)C=CC(=C4)F)SC5=CC=CC=C53<br />)CC1.C(=CC(=O)[O-])C(=O)[O-]
|
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| InChI |
1S/C20H19FN4S.C4H4O4/c1-24-8-10-25(11-9-24)19-18-14-4-2-3-5-17(14)26-20(18)23-16-12-13(21)6-7-15(16)22-19;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3,(H,22,23);1-2H,(H,5,6)(H,7,8)/b;2-1-
|
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| InChIKey |
RHPQQODEPSPFTF-BTJKTKAUSA-N
|
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| CAS Number |
CAS 221058-55-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | D(2) dopamine receptor | Target Info | Binder | [1] | |
| KEGG Pathway | Rap1 signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Gap junction | |||||
| Dopaminergic synapse | |||||
| Parkinson's disease | |||||
| Cocaine addiction | |||||
| Alcoholism | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Dopamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| References | |||||
| REF 1 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31. | ||||
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