Drug General Information
Drug ID	D0PP5M
Former ID	DIB009730
Drug Name	BPH-652
Synonyms	FX24B-04652; Dehydrosqualene synthase inhibitor (MRSA), AuricX
Drug Type	Small molecular drug
Indication	Hypercholesterolemia [ICD10:E78]		Investigative	[543910]
Company	AuricX Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C16H16K3O7PS
Canonical SMILES	[K+].[K+].[K+].S(=O)(=O)([O-])C(P(=O)([O-])[O-])CCCc1cc<br />cc(c1)Oc1ccccc1
PubChem Compound ID	25244957
Target and Pathway
Target(s)	Squalene synthetase	Target Info	Inhibitor	[543910]
BioCyc Pathway	Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
	Cholesterol biosynthesis III (via desmosterol)
	Cholesterol biosynthesis I
	Superpathway of cholesterol biosynthesis
	Epoxysqualene biosynthesis
KEGG Pathway	Steroid biosynthesis
	Metabolic pathways
	Biosynthesis of antibiotics
PANTHER Pathway	Cholesterol biosynthesis
PathWhiz Pathway	Steroid Biosynthesis
Reactome	Cholesterol biosynthesis
	PPARA activates gene expression
	Activation of gene expression by SREBF (SREBP)
WikiPathways	Statin Pathway
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Activation of Gene Expression by SREBP (SREBF)
	SREBP signalling
	Cholesterol Biosynthesis
	Cholesterol biosynthesis
References
Ref 543910	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645).
Ref 543910	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 645).

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