Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0PN9E
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| Former ID |
DIB016057
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| Drug Name |
SK-951
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| Indication | Gastrointestinal disease [ICD10:K00-K93] | Terminated | [1] | ||
| Company |
Sanwa Kagaku Kenkyusho Co Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c12c(cc(c(c1C[C@@H](O2)C)N)Cl)C(=O)NCCC12N(CCC1)CCC2.C(<br />=O)(/C=C/C(=O)O)O
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| CAS Number |
CAS 166743-12-0
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 4 receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT4 type receptor mediated signaling pathway | |||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 4 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011740) | ||||
| REF 2 | Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors. Jpn J Pharmacol. 1999 Feb;79(2):203-12. | ||||
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