Drug General Information
Drug ID
D0PG8O
Former ID
DIB010836
Drug Name
Naltrexone
Synonyms
Depotrex; Naltrel; Vivitrex; Vivitrol; Naltrexone Depot; IBS therapy, Pain Therapeutics; Irritable bowel syndrome therapy, Pain Therapeutics; PTI-901; XR-NTX; Naltrexone (sustained release), DAS; Naltrexone (sustained release), elbion; Naltrexone depot (injectable suspension), DrugAbuse Sciences; Naltrexone depot (injectable suspension), elbion; Opioid antagonists (irritable bowel syndrome), Pain Therapeutics; Naltrexone (low-dose), Pain Therapeutics; Naltrexone (polymer microcapsule depot, opioid addiction/alcohol dependency), Biotek; Naltrexone (transdermal, alcohol/opioid dependence), Syntropharma; Naltrexone (once-monthly controlled-release, Medisorb), Alkermes
Drug Type
Small molecular drug
Indication Alcohol dependence [ICD10:F10] Approved [551871]
Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 4 [525241], [539012]
Company
Tni biotech; DrugAbuse Sciences; Alkermes Inc
Structure
Download
2D MOL

3D MOL

Formula
C20H23NO4
InChI
InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
InChIKey
DQCKKXVULJGBQN-XFWGSAIBSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Opioid receptor Target Info Antagonist [529288], [551871]
References
Ref 525241ClinicalTrials.gov (NCT02478489) Alcohol Use Disorder hOsPital Treatment Trial.
Ref 539012(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1639).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 529288An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study. Arch Gen Psychiatry. 2008 Feb;65(2):135-44.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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