Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0P9LO
|
||||
| Former ID |
DIB011760
|
||||
| Drug Name |
BP-2.94
|
||||
| Synonyms |
FUB-94; (-)-2-[1-[2-(4-Imidazolyl)-1(R)-methylethylimino]-1-phenylmethyl]phenol
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Discontinued in Phase 2 | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H19N3O
|
||||
| Canonical SMILES |
CC(CC1=CN=CN1)NC(=C2C=CC=CC2=O)C3=CC=CC=C3
|
||||
| InChI |
1S/C19H19N3O/c1-14(11-16-12-20-13-21-16)22-19(15-7-3-2-4-8-15)17-9-5-6-10-18(17)23/h2-10,12-14,22H,11H2,1H3,(H,20,21)/b19-17+
|
||||
| InChIKey |
NDSIMLLWOSEGGX-HTXNQAPBSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H3 receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Reactome | Histamine receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Monoamine Transport | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008192) | ||||
| REF 2 | Sleep and waking during acute histamine H3 agonist BP 2.94 or H3 antagonist carboperamide (MR 16155) administration in rats. Neuropsychopharmacology. 1996 Jul;15(1):31-5. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.