Drug General Information
Drug ID
D0P8TX
Former ID
DIB018390
Drug Name
[3H]ramatroban
Synonyms
[3H]BAY u3405; [3H]Bay u 3405; [3H]baynas
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539211]
Structure
Download
2D MOL
Formula
C21H21FN2O4S
InChI
InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
InChIKey
LDXDSHIEDAPSSA-OAHLLOKOSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [527831]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539211(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1910).
Ref 527831CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. Epub 2005 Oct 27.

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