Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0P4DG
|
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| Former ID |
DIB014818
|
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| Drug Name |
S-070
|
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| Synonyms |
S-070; S-158; Targeted synergy program (solid tumor), Sentinel Oncology; Chk1/PARP-1 inhibitors (cancer); Chk1/PARP-1 inhibitors (cancer), Sentinel Oncology
|
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Investigative | [543531] | ||
| Company |
Sentinel Oncology Ltd
|
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| Target and Pathway | |||||
| Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [543531] | |
| Poly [ADP-ribose] polymerase-1 | Target Info | Inhibitor | [543709] | ||
| PANTHER Pathway | FAS signaling pathway | ||||
| Reactome | Activation of ATR in response to replication stress | ||||
| Processing of DNA double-strand break ends | |||||
| Presynaptic phase of homologous DNA pairing and strand exchange | |||||
| G2/M DNA damage checkpoint | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-5696400:Dual Incision in GG-NER | |||||
| WikiPathways | DNA Damage Response | ||||
| Signaling by SCF-KIT | |||||
| ATM Signaling Pathway | |||||
| Retinoblastoma (RB) in Cancer | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrated Cancer pathway | |||||
| Cell Cycle | |||||
| Cell Cycle Checkpoints | |||||
| miRNA Regulation of DNA Damage ResponseWP314:FAS pathway and Stress induction of HSP regulation | |||||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | |||||
| Nanoparticle triggered regulated necrosis | |||||
| Corticotropin-releasing hormone | |||||
| References | |||||
| Ref 543531 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1987). | ||||
| Ref 543709 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). | ||||
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