| Drug General Information |
| Drug ID |
D0P3OH
|
| Former ID |
DNC005987
|
| Drug Name |
3-chlorophenyl 2-oxo-2H-chromene-3-carboxylate
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H9ClO4
|
| Canonical SMILES |
C1=CC=C2C(=C1)C=C(C(=O)O2)C(=O)OC3=CC(=CC=C3)Cl
|
| InChI |
1S/C16H9ClO4/c17-11-5-3-6-12(9-11)20-15(18)13-8-10-4-1-2-7-14(10)21-16(13)19/h1-9H
|
| InChIKey |
HDIMJBWUBWTFNJ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Coagulation factor Xa |
Target Info |
Inhibitor |
[1]
|
|---|
| Coagulation factor IIa |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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Complement and coagulation cascadeshsa04080:Neuroactive ligand-receptor interaction
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Complement and coagulation cascades
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Regulation of actin cytoskeleton
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NetPath Pathway
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TCR Signaling Pathway
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PANTHER Pathway
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Blood coagulationP00011:Blood coagulation
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Pathway Interaction Database
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Beta2 integrin cell surface interactionsthrombin_pathway:Thrombin/protease-activated receptor (PAR) pathway
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Angiopoietin receptor Tie2-mediated signaling
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FOXA2 and FOXA3 transcription factor networks
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PAR4-mediated thrombin signaling events
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Syndecan-4-mediated signaling events
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PAR1-mediated thrombin signaling events
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PathWhiz Pathway
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CoagulationPW000047:Vitamin K Metabolism
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Coagulation
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Reactome
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Extrinsic Pathway of Fibrin Clot Formation
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Intrinsic Pathway of Fibrin Clot Formation
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Common Pathway of Fibrin Clot Formation
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Gamma-carboxylation of protein precursors
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Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
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Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
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Removal of aminoterminal propeptides from gamma-carboxylated proteins
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Cell surface interactions at the vascular wall
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Peptide ligand-binding receptors
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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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G alpha (q) signalling events
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Thrombin signalling through proteinase activated receptors (PARs)
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WikiPathways
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Complement and Coagulation Cascades
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Human Complement System
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PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
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Blood Clotting Cascade
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Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
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Regulation of Actin Cytoskeleton
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IL1 and megakaryotyces in obesity
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Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
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Gastrin-CREB signalling pathway via PKC and MAPK
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Thrombin signalling through proteinase activated receptors (PARs)
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Platelet Aggregation (Plug Formation)
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GPCR ligand binding
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GPCR downstream signaling
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Formation of Fibrin Clot (Clotting Cascade)
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Cell surface interactions at the vascular wall
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Folate Metabolism
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Vitamin B12 Metabolism
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Selenium Micronutrient Network
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| References |
| REF 1 | J Med Chem. 2005 Dec 1;48(24):7592-603.3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa. |
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