Drug General Information
Drug ID	D0P3IZ
Former ID	DIB007231
Drug Name	E-2040
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Terminated	[546598]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(c(cc(N2CCN(CC2)CCO)c1)[C@H](F)CC)Cl)c1c(C#N)cccc1.<br />Cl
CAS Number	CAS 172732-21-7
Target and Pathway
Target(s)	5-HT 2 receptor	Target Info	Modulator	[546599]
	D(3) dopamine receptor	Target Info	Modulator	[546599]
	D(2) dopamine receptor	Target Info	Modulator	[546599]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction
	Dopaminergic synapsehsa04015:Rap1 signaling pathway
	cAMP signaling pathway
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
	GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 546598	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009126)
Ref 546599	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009126)

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